Central subfield thickness

1. Alzheimer's disease is associated with central subfield thickness in humans.

   “Comparing AD to noncarriers, CST ( p = 0.014), 6mm circle PD ( p = 0.025), 6mm circle VD ( p = 0.036), and 6mm inner ring VD ( p = 0.042) were significantly lower in AD vs APOE ε4 noncarriers.”

   HumansAD vs noncarriers

   Multimodal Retinal Imaging in Asymptomatic APOE ε4 Carriers, APOE ε4 Noncarriers, and Alzheimer's Disease

   AAIC 2025 abstract·24 Dec 2025

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