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Cellular levels of lamina-associated proteins

Biomarker

1 paper1 finding

  • Cells1

Interventions

1

Modified oligonucleotide targeted to the activated cryptic splice site

upin human cells1

1 study

  1. Modified oligonucleotide targeted to the activated cryptic splice site improves cellular levels of lamina-associated proteins in human cells.

    “the aberrant nuclear distribution and cellular levels of lamina-associated proteins are rescued”

    Cellsin HGPS fibroblasts

    Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

    Nature medicine6 Mar 2005

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