2 findings
Age-related DNA methylation variability
upin humans1
Cellular composition is associated with age-related DNA methylation variability in humans.
“find high levels of confounding between age-related variability and cellular composition at the CpG level”
Humansblood
Accounting for cellular heterogeneity is critical in epigenome-wide association studies
Genome biology4 Feb 2014
DNA methylation variability
upin humans1
Cellular composition is associated with DNA methylation variability in humans.
“cellular composition explains much of the observed variability in DNA methylation”
Humansblood
Accounting for cellular heterogeneity is critical in epigenome-wide association studies
Genome biology4 Feb 2014
National Institute of Diabetes and Digestive and Kidney DiseasesUS$1.4m
In a mouse heart attack experiment, particles released by aged stem cells engineered to produce more apelin, a signalling protein, improved heart function.In a mouse heart attack experiment, particles released by aged stem cells engineered to produce more apelin, a signalling protein, improved heart function.
Experiments found increased release of the hormone in aged mice with normal or reduced responses to insulin, which lowers blood sugar.Experiments found increased release of the hormone in aged mice with normal or reduced responses to insulin, which lowers blood sugar.