Cellular circadian period

1. Cellular circadian period is associated with p-Tau217 in humans.

   “A longer intrinsic circadian period was selectively associated with higher pTau-217, NfL, and GFAP levels and medial temporal atrophy”

   Humansin older adults with cognitive complaintsn = 135

   Cellular circadian period and its deviation associate with Alzheimer's pathology and brain aging in cognitively impaired older adults

   Proceedings of the National Academy of Sciences of the United States of America·2 Mar 2026

More on p-Tau217

1. Cellular circadian period predicts clinical decline in humans (HR = 4.41, 95% CI: 1.52 to 12.83).

   “Both longer period (HR = 4.41, 95% CI: 1.52 to 12.83) and greater Δ-period (HR = 2.65, 95% CI: 1.03 to 6.86) independently predicted faster clinical decline.”

   Humansin older adults with cognitive complaintsn = 135

   Cellular circadian period and its deviation associate with Alzheimer's pathology and brain aging in cognitively impaired older adults

   Proceedings of the National Academy of Sciences of the United States of America·2 Mar 2026

1. Cellular circadian period is associated with NfL in humans (p <0.001).

   “neural injury and degeneration (plasma NfL, p <0.001, large effect size; MRI Schelten's scale, p = 0.033, small effect size)”

   Humansolder adults with cognitive complaintsn = 135

   Associations of ex‐vivo cellular circadian period with aging, tau, neurodegeneration, inflammation and clinical progression in older adults with cognitive impairment: Findings from BICWALZS cohort

   AAIC 2025 abstract·23 Dec 2025

More on NfL

1. Cellular circadian period is associated with pTau-217 in humans (p = 0.012).

   “The cellular circadian period was significantly associated with tau proteinopathy (plasma pTau‐217, p = 0.012, small effect size)”

   Humansolder adults with cognitive complaintsn = 135

   Associations of ex‐vivo cellular circadian period with aging, tau, neurodegeneration, inflammation and clinical progression in older adults with cognitive impairment: Findings from BICWALZS cohort

   AAIC 2025 abstract·23 Dec 2025

More on pTau-217

1. Cellular circadian period raises the risk of clinical progression in humans (HR=3.59, p = 0.01).

   “Survival analysis showed that longer cellular circadian period were associated with faster clinical progression (HR=3.59, p = 0.01).”

   Humansolder adults with cognitive complaintsn = 135

   Associations of ex‐vivo cellular circadian period with aging, tau, neurodegeneration, inflammation and clinical progression in older adults with cognitive impairment: Findings from BICWALZS cohort

   AAIC 2025 abstract·23 Dec 2025