Circadian period deviation from 24 h

Circadian period deviation from 24 h is associated with cognitive function in humans.

“In contrast, greater Δ-period was associated with older age, poorer cognitive performance across multiple domains, and more widespread brain atrophy”

Humansin older adults with cognitive complaintsn = 135

Cellular circadian period and its deviation associate with Alzheimer's pathology and brain aging in cognitively impaired older adults

Proceedings of the National Academy of Sciences of the United States of America·2 Mar 2026

Circadian period deviation from 24 h predicts clinical decline in humans (HR = 2.65, 95% CI: 1.03 to 6.86).

“Both longer period (HR = 4.41, 95% CI: 1.52 to 12.83) and greater Δ-period (HR = 2.65, 95% CI: 1.03 to 6.86) independently predicted faster clinical decline.”

Humansin older adults with cognitive complaintsn = 135

Cellular circadian period and its deviation associate with Alzheimer's pathology and brain aging in cognitively impaired older adults

Proceedings of the National Academy of Sciences of the United States of America·2 Mar 2026