Circadian period deviation from 24 hours

Circadian period deviation from 24 hours impair cognitive function in humans (p = 0.016).

“Deviation from 24 hours was strongly associated with age ( p = 0.02, FDR‐p=0.06), neurodegeneration (MRI Schelten's scale, p = 0.004), cognitive decline (MMSE, p = 0.016)”

Humansolder adults with cognitive complaintsn = 135

Associations of ex‐vivo cellular circadian period with aging, tau, neurodegeneration, inflammation and clinical progression in older adults with cognitive impairment: Findings from BICWALZS cohort

AAIC 2025 abstract·23 Dec 2025