CDKN2A and CXCL8 transcript expression

1. Metformin decreases CDKN2A and CXCL8 transcript expression in human cells.

   “it attenuated the expression of key senescence-associated transcripts, including CDKN2A and components of the senescence-associated secretory phenotype (SASP) such as CXCL8”

   Cellscisplatin-induced senescenceinduced pluripotent stem cell-derived motor neurons

   Metformin Partially Modulates Cisplatin-Induced Neuronal Senescence but Does Not Prevent Rat Peripheral Sensory Hypersensitivity

   Toxicology mechanisms and methods·12 Oct 2026

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