Brain PUFA content

1. Brain PUFA content is associated with cognitive impairment.

   “Age-related decline in brain PUFA content is a consistent finding across species and is linked to lower synaptic density, neuronal loss, and cognitive impairment.”

   Reviewage-related decline in brain PUFA contentbrain

   Polar lipids, omega-3 polyunsaturated fatty acids homeostasis, and brain aging: Mechanisms, dietary sources, and neuroprotection

   Nutrition research (New York, N.Y.)·21 Apr 2026

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