Brain aging estimates
Biomarker1 finding
Associations
1DNA methylation-based epigenetic clocks
mixedin humans1
1 study
DNA methylation-based epigenetic clocks
mixedin humans1
Brain aging estimates are associated with DNA methylation-based epigenetic clocks in humans.
HumansDensely sampled participantfemalesn = 1
Estimated brain-age gap rises by three years in pregnancy · Research square · 13 Aug 2026 · Preprint
Latest
13Estimated brain-age gap rises by three years in pregnancy
Brain-age gap estimates rose by about three years during pregnancy and fell below pre-conception levels by 16 months postpartum in a longitudinal…Brain-age gap estimates rose by about three years during pregnancy and fell below pre-conception levels by 16 months postpartum in a longitudinal study.
Model estimates brain aging speed from local MRI changes
Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns…Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.
Compartment-resolved brain aging reveals distinct vascular and neurodegenerative pathways
Separating white and gray matter brain age highlights early cardiometabolic risks and divergent links to amyloid and tau pathology.Separating white and gray matter brain age highlights early cardiometabolic risks and divergent links to amyloid and tau pathology.