Atrial fibrillation polygenic risk score

1. Atrial fibrillation polygenic risk score predicts incident atrial fibrillation in humans (Adjusted for CHARGE-AF score and sex).

   “AF PRS, LASr and LASct retained significant predictive value for incident AF after adjustment for baseline AF risk by CHARGE-AF score and sex.”

   HumansAdjusted for CHARGE-AF score and sexMedian 8.3 (7.9-8.9) yearsWomen and mensn = 3,173

   Polygenic risk and echocardiographic markers of left atrial dysfunction improve prediction of incident atrial fibrillation: insights from the akershus cardiac examination (ACE) 1950 Study

   ESC Congress 2026 abstract·Oct 26, 2026

2. Atrial fibrillation polygenic risk score is associated with incident atrial fibrillation in humans (High atrial fibrillation polygenic risk score defined as ≥0.858 (top quintile)).

   “High polygenic risk score was significantly associated with incident AF”

   HumansHigh atrial fibrillation polygenic risk score defined as ≥0.858 (top quintile)Median follow-up of 15.6 yearsn = 386,154

   Genetic links to irregular heartbeat vary by age and sex

   Journal of the American Heart Association·Oct 23, 2026

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1. Atrial fibrillation polygenic risk score predicts atrial fibrillation in humans (Mitral valve disease; intermediate polygenic risk score) (HR 1.7; P = 0.03 for intermediate PRS).

   “PRS was independently associated with incident AF in MV disease (HR: 1.7, P = 0.03 for intermediate PRS; HR: 2.3, P = 0.002 for high PRS)”

   HumansMitral valve disease; intermediate polygenic risk score

   Atrial Fibrillation in Valvular Heart Disease: Assessing the Impact of Genetics in the UK Biobank

   JACC. Advances·Oct 20, 2026

2. Atrial fibrillation polygenic risk score predicts atrial fibrillation in nonischemic cardiomyopathy (HR per 1 SD: 1.30; 95% CI: 1.18-1.42).

   “PRSAF was an important predictor of NOAF (HR per 1 SD: 1.30; 95% CI: 1.18-1.42)”

   Humansin nonischemic cardiomyopathyn = 2,661

   Polygenic Risk of New Onset Atrial Fibrillation in Nonischemic Cardiomyopathy

   JACC. Clinical electrophysiology·Mar 5, 2026

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1. Atrial fibrillation polygenic risk score is associated with new-onset atrial fibrillation in humans (European and non-European ancestry groups) (European OR 1.68 vs non-European OR 1.25).

   “The AF-PRS was strongly associated with incident AF, with stronger effect estimates in European versus non-European ancestry groups (European OR 1.68 vs non-European OR 1.25).”

   HumansEuropean and non-European ancestry groups

   Ethnic differences in new-onset atrial fibrillation using multidimensional data

   ESC Congress 2026 abstract·Oct 26, 2026

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1. Atrial fibrillation polygenic risk score predicts non-ischemic cardiomyopathy in humans (adjusted for sex, smoking status, BMI, and hypertension) (HR = 1.09 [1.03, 1.15], p < 0.001).

   “a linear AF-PRS (15% increments) was specifically predictive of increased hazard risk of NICM (HR = 1.09 [1.03, 1.15], p < 0.001).”

   Humansadjusted for sex, smoking status, BMI, and hypertensionn = 16,801

   Atrial Fibrillation Polygenic Risk Score (AF-PRS) Predicts Non-Ischemic Cardiomyopathy: A Single-Center Retrospective Cohort Study of 16,801 Individuals

   medRxiv·Mar 24, 2026Preprint

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1. Atrial fibrillation polygenic risk score is linked with a higher risk of sick sinus syndrome in humans (HR 1.82, 95% CI 1.45 to 2.29).

   “The high-PRS and intermediate-PRS groups were related to 82% (HR 1.82, 95% CI 1.45 to 2.29) and 32% (HR 1.32, 95% CI 1.07 to 1.62) higher SSS risks, respectively.”

   Humansn = 405,869

   Comprehensive risk factor analysis of sick sinus syndrome: a genetic, sociodemographic, clinical and laboratory investigation using the UK Biobank data

   Heart (British Cardiac Society)·Jan 29, 2026

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1. Atrial fibrillation polygenic risk score is associated with insular cortical thickness in humans (p < 0.005).

   “insular thinning correlated with elevated AF PRS and systolic BP (p < 0.005).”

   Humansinsula

   Genetic and Brain MRI Markers Reveal Cardiovascular Burden Across Brain Disorders

   AHA Scientific Sessions 2025 abstract·Nov 3, 2025

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