Heart failure polygenic risk score

1. Heart failure polygenic risk score was not clearly linked with heart failure prediction discrimination in humans (Addition to clinical factors and ECG-AI in UKB and MGBB) (PREVENT-HF + ECG2HF AUROC: UKB 0.811 (0.787–0.834); MGBB 0.810 (0.790–0.831), nearly identical to Tri-HF).

   “population-level HF risk prediction using clinical factors and ECG-AI is not meaningfully improved by the addition of HF PRS.”

   HumansAddition to clinical factors and ECG-AI in UKB and MGBB

   Combining health records and heart tests predicts heart failure

   ESC Congress 2026 abstract·Oct 26, 2026

1. Heart failure polygenic risk score is linked with lower hippocampal volume in humans (β = –0.21, SE = 0.07, p = 0.001).

   “hippocampal volume loss was significantly associated with high HF PRS (β = –0.21, SE = 0.07, p = 0.001)”

   Humanshippocampus

   Genetic and Brain MRI Markers Reveal Cardiovascular Burden Across Brain Disorders

   AHA Scientific Sessions 2025 abstract·Nov 3, 2025

More on Hippocampal volume

1. Heart failure polygenic risk score is associated with new-onset atrial fibrillation in humans (European and non-European ancestry groups) (European OR 1.30 vs non-European OR 1.08).

   “The HF-PRS showed a modest association (European OR 1.30 vs non-European OR 1.08).”

   HumansEuropean and non-European ancestry groups

   Ethnic differences in new-onset atrial fibrillation using multidimensional data

   ESC Congress 2026 abstract·Oct 26, 2026

More on New-onset atrial fibrillation