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Non-ischemic cardiomyopathy

There are 16 papers on non-ischemic cardiomyopathy in aging research: 15 observational studies in people, 1 review. The newest story, Nov 7, 2026: “Early heart conditions linked to later serious heart problems”.

Disease

16 papers study it5 more mention it6 findings

4 new papers in 30 daysSee all 21 papers on non-ischemic cardiomyopathy

“PCD conferred the greatest risk of incident CM/VA among SCPs (OR 7.9 vs controls, 95% CI 6.3-9.9, p<0.001”
Sentinel Cardiac Presentations Identify Patients at High Risk of Incident Nonischemic Cardiomyopathy and Ventricular ArrhythmiaAHA Scientific Sessions 2026 abstract2026doi:10.1161/circ.154.suppl_1.17584
  • Humans15

Interventions

1

Physical activity

no changein humans1

1 study

  1. Physical activity was not clearly linked with non-ischemic cardiomyopathy in phenotype-negative carriers of cardiomyopathy-associated rare variants (G+P-).

    “No associations were observed between MVPA and risk of NICM or VA in G+P- individuals.”

    Humansin phenotype-negative carriers of cardiomyopathy-associated rare variants (G+P-)

    Effects of Device-Measured Physical Activity on Disease Progression and Cardiovascular Outcomes in Phenotype-Negative Carriers of Cardiomyopathy-Associated Rare Variants

    AHA Scientific Sessions 2025 abstract

More on Physical activity

Effects

1

Time to first shock

downin humans1

1 study

  1. Non-ischemic cardiomyopathy is linked with lower time to first shock in humans (non-ischemic vs ischemic cardiomyopathy) (7.7 vs. 32.2 months).

    “Patients with non-ischemic cardiomyopathy experienced earlier shocks (7.7 vs. 32.2 months, p < 0.05).”

    Humansnon-ischemic vs ischemic cardiomyopathy

    Implantable cardiac defibrillator outcomes in octogenarians

    Journal of arrhythmia

Associations

4

Younger age at sentinel cardiac presentation diagnosis

upin humans1OR 3.1

1 study

  1. younger age at sentinel cardiac presentation diagnosis predicts non-ischemic cardiomyopathy in humans (OR 3.1 per 10-years, 95% CI 2.5-3.9).

    “Younger age at SCP diagnosis (OR 3.1 per 10-years, 95% CI 2.5-3.9, p<0.001)”

    Humans

    Early heart conditions linked to later serious heart problems

    AHA Scientific Sessions 2026 abstract

Pathogenic CM variants

upin humans1OR 2.3

1 study

  1. pathogenic CM variants are linked with a higher risk of non-ischemic cardiomyopathy in humans (OR 2.3, 95% CI 1.3-4.0).

    “pathogenic CM variants (OR 2.3, 95% CI 1.3-4.0, p=0.003) were significant predictors of incident CM/VA.”

    Humans

    Early heart conditions linked to later serious heart problems

    AHA Scientific Sessions 2026 abstract

Premature conduction disease

upin humans1OR 7.9

1 study

  1. Premature conduction disease is linked with a higher risk of non-ischemic cardiomyopathy in humans (OR 7.9, 95% CI 6.3-9.9).

    “PCD conferred the greatest risk of incident CM/VA among SCPs (OR 7.9 vs controls, 95% CI 6.3-9.9, p<0.001”

    Humans

    Early heart conditions linked to later serious heart problems

    AHA Scientific Sessions 2026 abstract

More on Premature conduction disease

Atrial fibrillation polygenic risk score

upin humans1HR 1.09

1 study

  1. Atrial fibrillation polygenic risk score predicts non-ischemic cardiomyopathy in humans (adjusted for sex, smoking status, BMI, and hypertension) (HR = 1.09 [1.03, 1.15], p < 0.001).

    “a linear AF-PRS (15% increments) was specifically predictive of increased hazard risk of NICM (HR = 1.09 [1.03, 1.15], p < 0.001).”

    Humansadjusted for sex, smoking status, BMI, and hypertensionn = 16,801

    Atrial Fibrillation Polygenic Risk Score (AF-PRS) Predicts Non-Ischemic Cardiomyopathy: A Single-Center Retrospective Cohort Study of 16,801 Individuals

    medRxivPreprint

More on Atrial fibrillation polygenic risk score

Trial sponsors

Funding

1 grant since 2021

National Heart, Lung, and Blood Institute$354K

Latest

Dec 2025: 1Jan 2026: 1Feb 2026: 0Mar 2026: 2Apr 2026: 1May 2026: 1Jun 2026: 0Jul 2026: 1Aug 2026: 0Sep 2026: 0Oct 2026: 2Nov 2026: 211 papers in 12 months
AHA Scientific Sessions 2026 Abstract

Early heart conditions linked to later serious heart problems

Heart muscle disease or serious rhythm problems occurred in 11% of people with early warning conditions, compared with 1.8% of controls.Heart muscle disease or serious rhythm problems occurred in 11% of people with early warning conditions, compared with 1.8% of controls.

Cohort · 165,082 peoplePopulations
Paper
ESC Congress 2026 Abstract

Rare heart variants are linked to higher cardiovascular risk

Carriers’ hazard ratios—a measure of relative risk—were 1.72 for European and 1.88 for non-European ancestry compared with non-carriers.Carriers’ hazard ratios—a measure of relative risk—were 1.72 for European and 1.88 for non-European ancestry compared with non-carriers.

Cohort studyPopulations
Paper

See all 21 papers on non-ischemic cardiomyopathy

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