There are 2 papers on arachidonic acid/docosahexaenoic acid ratio in aging research: 1 trial and 1 observational study in people.
2 papers study it3 findings
See all 2 papers on arachidonic acid/docosahexaenoic acid ratio
“Arachidonic acid and DHA containing PL species, ε4-status and Aβ42/Aβ40 ratios provided 91% accuracy in detecting MCI/AD.”
- Human trial1
- Humans1
Interventions
1Fish oil
downin humans1
1 study
Fish oil
downin humans1
Fish oil is linked with lower arachidonic acid/docosahexaenoic acid ratio in humans (even among ε4 carriers).
“Fish oil/omega-3 fatty acid consumption was associated with lower AA/DHA ratios even among ε4 carriers.”
Humanseven among ε4 carriers
Aging
Upstream
1APOE
upin mice1
1 study
APOE
upin mice1
APOE increases arachidonic acid/docosahexaenoic acid ratio in mice (compared to EFAD mice with other isoforms).
“High plasma AA/DHA ratios were observed in E4FAD compared to EFAD mice with other isoforms.”
Animalscompared to EFAD mice with other isoforms
Aging
Associations
1Mild cognitive impairment/Alzheimer's disease
upin humans1+91% accuracy
1 study
Mild cognitive impairment/Alzheimer's disease
upin humans1+91% accuracy
Arachidonic acid/docosahexaenoic acid ratio predicts mild cognitive impairment/Alzheimer's disease in preclinical AD cohort converting within 3 years (91% accuracy).
“Arachidonic acid and DHA containing PL species, ε4-status and Aβ42/Aβ40 ratios provided 91% accuracy in detecting MCI/AD.”
Humansin preclinical AD cohort converting within 3 yearsn = 195
Aging