Current Atherosclerosis Reports
Targeting Apolipoprotein C-III in Hypertriglyceridemia: Implications for Pancreatitis and Cardiovascular risk
ReviewAcute pancreatitis
Papers on apoC3
29 papers8 new in 30 days
Monday, October 26
ESC Congress 2026 Abstract
Apolipoprotein and inflammatory biomarker changes following marked triglyceride reduction with the GalNAc-conjugated APOC3 siRNA RBD5044
Randomized trial in peopleInterventions
ESC Congress 2026 Abstract
ION775, a long-acting siRNA targeting APOC3: single-dose, 12-month results in participants with moderate hypertriglyceridemia
Randomized trial in 40 peopleHypertriglyceridemia
ESC Congress 2026 Abstract
Mechanisms underlying ApoC3-mediated PM2.5-Induced atherosclerotic cardiovascular disease
Experiments in miceAPOC3
Tuesday, October 20
Current Hypertension Reviews
Cognitive Functions and Gene Polymorphism Associated with Cardiovascular Risk in Young Adults vs. Patients with Arterial Hypertension
Cross-sectional study of 152 peopleArterial hypertension
Saturday, October 17
Nutrition Reviews
Comparative Effects of Low-Fat and High-Fat Diets on Non-HDL Cholesterol, Apolipoproteins, and Lipoprotein Ratios: A Meta-Analysis of Randomized Controlled Trials
Meta-analysis of randomized trialsInterventions
Tuesday, October 13
European Journal of Pharmacology
Effectiveness and Safety of Target-Specific RNA-Based Lipid-Lowering Therapies: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta-analysis of randomized trialsInterventions
Wednesday, October 7
Annual Review of Pharmacology and Toxicology
Small Interfering RNA in Cardiovascular Disease: A New Frontier in Precision Medicine
ReviewCardiovascular disease
Tuesday, September 22
The Journal of Nutrition
Dietary Patterns Are Key Predictors of Cardiovascular Risk Beyond Genetic Risk Across Metabolic Syndrome Trajectories in A Korean Prospective Cohort Study
Cohort study of 58,701 peopleCardiovascular disease
Thursday, September 10
GeroScience
Apolipoprotein(a)-rich electronegative HDL accelerates vascular aging and atherosclerosis by inducing endothelial senescence
Cohort study of 131 peopleCellular senescence
Monday, August 24
Metabolism
Discovery of functional variants regulating lipid metabolism in an East Asian population
Genetic association study of 72,298 peopleLipid and ceramide metabolism
Wednesday, August 12
Friday, July 17
Friday, June 26
Journal of Cardiovascular Pharmacology
Silencing Triglycerides: The Clinical Impact of Plozasiran and apoC-III Inhibition in Severe Hypertriglyceridemia
ReviewInterventions
Monday, March 30
Circulation
Effect of APOC3 Inhibition With Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study
Randomized trial in 468 peopleCoronary atherosclerosis
Wednesday, March 11
medRxiv
Triglyceride-rich lipoproteins, low-density lipoproteins, and risk of abdominal aortic aneurysm
Preprint: Mendelian randomization in 383,983 peopleMechanisms
Tuesday, December 2
EMBO Molecular Medicine
Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever
Study in peopleDNA damage response
Friday, March 29
Atherosclerosis
Drug target Mendelian randomization supports apolipoprotein C3-lowering for lipoprotein-lipid levels reductions and cardiovascular diseases prevention
Mendelian randomization in 35,378 peopleMechanisms
Tuesday, March 5
Thursday, December 21
Aging
Causal effects of lipid-lowering therapies on aging-related outcomes and risk of cancers: a drug-target Mendelian randomization study
Mendelian randomization in peoplePopulations
Monday, December 18
Journal of the American Heart Association
Unraveling Potential Sex-Specific Effects of Cardiovascular Medications on Longevity Using Mendelian Randomization
Mendelian randomization in 415,311 peopleInterventions
Tuesday, December 12
Lipids in Health and Disease
Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis
Mendelian randomization in 500,193 peoplePopulations
Sunday, April 24
Saturday, July 11
JAMA Network Open
Association of Apolipoprotein E in Lipoprotein Subspecies With Risk of Dementia
Study in peopleBiomarkers
Sunday, July 14
EBioMedicine
Genetically-predicted life-long lowering of low-density lipoprotein cholesterol is associated with decreased frailty: A Mendelian randomization study in UK biobank
Mendelian randomization in 378,161 peoplePopulations
Thursday, March 21
Journal of Proteome Research
Proteomic Analysis of Human Plasma during Intermittent Fasting
Trial in peopleInterventions
Wednesday, April 19
Neurobiology of Aging
Plasma apolipoproteins and physical and cognitive health in very old individuals
Cohort study of 1,067 peopleBiomarkers
Tuesday, March 8
Experimental Gerontology
No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes
Genetic association study of 1,281 peopleMechanisms
Wednesday, February 10
Nutrition
Nutritional habits, lifestyle, and genetic predisposition in cardiovascular and metabolic traits in Turkish population
Cross-sectional study in peoplePopulations