Alpha-synuclein aggregates

3 papers1 finding

Animals1
Model organisms1

Interventions

1

MAB47

downin mice1

1 study

MAB47 decreases alpha-synuclein aggregates in mice.
“displayed significant dose-dependent decrease of α-synuclein aggregates in brain in several mouse models”
Animalsα-synuclein transgenic micebrain
ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease
Neurobiology of disease1 Nov 2021

Funding

2 grants since 2016

The Michael J. Fox Foundation for Parkinson's Research

Latest

1 in 12 months

Annals of Neurology25 Dec

Age-Related Differences in the Association between REM Sleep and the Polygenic Risk for Parkinson's Disease

Cross-sectional study in peopleMechanisms

Experimental Neurology15 Oct

Lasmiditan ameliorates cortico-hippocampal pathology and improves cognition in aging parkinsonian mice

Experiments in miceParkinson's disease

Molecular Neurobiology24 Jul

Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models

Experiments in wormsInterventions

Bioorganic Chemistry24 Jul

Nanotechnology-enhanced neuroprotection: a novel idebenone nanoprodrug conjugate strategy for Parkinson's disease

Experiments in fliesParkinson's disease

bioRxiv3 Mar

The 5-HT1F Receptor Agonist Lasmiditan improves Cognition and Ameliorates Associated Cortico-Hippocampal Pathology in Aging Parkinsonian Mice

Preprint: experiments in animalsInterventions

Journal of Neurochemistry2 May

The role of age-associated alpha-synuclein aggregation in a conditional transgenic mouse model of Parkinson's disease: Implications for Lewy body formation

Experiments in animalsMechanisms

Experimental Gerontology28 Jan

Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies

ReviewBiomarkers

Neurobiology of Disease1 Nov

ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease

Experiments in miceParkinson's disease