Alpha-linolenic acid

1. Flaxseed oil increases alpha-linolenic acid in humans (+ 52.7-79.4 %).

   “α-Linolenic concentrations increased markedly (+ 52.7-79.4 %; p ≤ 0.01), whereas eicosapentaenoic acid and docosahexaenoic acid remained unchanged.”

   Human trialintegrated into individualized menu plans16 weeks

   A randomized parallel-designed study evaluating the effect of an app-based nutritional concept for weight reduction and further cardiovascular risk factors: Insights from the PreVA study

   Frontiers in nutrition·23 Sep 2026

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1. Alpha-linolenic acid predicts mild cognitive impairment in humans (AUC 0.66).

   “alpha‐linolenic acid, and palmitoleic acid in CSF unesterified, supernatant fluid, and nanoparticles fraction respectively effectively differentiated MCI from CU than Aβ, tau, and Aβ/tau with AUC of 0.70, 0.66 and 0.71”

   HumansCSF supernatant fluid fractioncerebrospinal fluid

   Cerebrospinal fluid fatty acids are better predictors of mild cognitive impairment than Aβ ₄₂ /tau ratio

   AAIC 2025 abstract·26 Dec 2025

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