1 paper1 finding
HLA
upin humans1
HLA is associated with allele frequency in humans.
“Furthermore, we identified 13 HLA alleles (9 HLA-I and 4 HLA-II) that occurred at greater frequency in very old individuals (age ≥90 years) as compared to younger individuals.”
Humans
Immunogenetics of longevity and its association with human endogenous retrovirus K
Frontiers in agingFeb 4, 2025
A yearly rise of at least 7.5% in mutated gene copies’ share best predicted cancer progression among patients with unexplained low counts of certain white blood cells.A yearly rise of at least 7.5% in mutated gene copies’ share best predicted cancer progression among patients with unexplained low counts of certain white blood cells.
Women carrying variants classed as harmful or likely harmful made up 0.84% of women studied and 5.2% of breast cancer cases.Women carrying variants classed as harmful or likely harmful made up 0.84% of women studied and 5.2% of breast cancer cases.
In 364 cardiac surgery patients, age (odds ratio 1.71 per decade) and a PITX2 variant (odds ratio 1.91) independently predicted postoperative atrial fibrillation, while…In 364 cardiac surgery patients, age (odds ratio 1.71 per decade) and a PITX2 variant (odds ratio 1.91) independently predicted postoperative atrial fibrillation, while inflammatory markers did not.
Whole-genome sequencing of eight coral colonies showed somatic mutations followed power-law distributions, faced purifying selection, and helped age a colony to nearly a…Whole-genome sequencing of eight coral colonies showed somatic mutations followed power-law distributions, faced purifying selection, and helped age a colony to nearly a century.