Research Square
Deleting an immune-related gene eased bone loss in female mice
An experiment compared female mice with and without an immune-regulating gene after ovary removal, finding higher bone density in mice without it.An experiment compared female mice with and without an immune-regulating gene after ovary removal, finding higher bone density in mice without it.
Preprint: mouse studyBones and joints
Who was studiedOvariectomized female mice, 12 weeks, against wild-type ovariectomized female mice
What changedBone density was higher in Crlf2-knockout female mice with ovaries removed than in wild-type mice with ovaries removed
The catchKnockout methods name Sestrin1 as the target, conflicting with the claimed Crlf2 deletion