CRLF2

Gene

2 papers study it2 findings

HGNC NCBI Gene Taxon

1 new paper in 30 daysSee all 2

None of its findings points the other way.

1 lab

Animals2

Effects

JAK2/STAT3 signaling

upin mouse cells1

1 study

CRLF2 activates JAK2/STAT3 signaling in mouse cells.
“CRLF2 directly binds to JAK2, activates the JAK2/STAT3 signaling pathway, promotes Stat3 phosphorylation and nuclear translocation”
Cells
Deleting an immune-related gene eased bone loss in female mice
Research SquareOct 27, 2026Preprint

osteogenic differentiation

downin mouse cells1

1 study

CRLF2 inhibits osteogenic differentiation in mouse cells.
“overexpression of CRLF2 significantly inhibited the differentiation of MC3T3-E1 cells and primary BM cells into osteoblasts, and knockdown had the opposite effect.”
CellsCRLF2 overexpression; knockdown produced the opposite effectMC3T3-E1 cells and primary bone marrow cells
Deleting an immune-related gene eased bone loss in female mice
Research SquareOct 27, 2026Preprint

Latest

1 paper in 12 months

Research SquareOct 28

Deleting an immune-related gene eased bone loss in female mice

An experiment compared female mice with and without an immune-regulating gene after ovary removal, finding higher bone density in mice without it.An experiment compared female mice with and without an immune-regulating gene after ovary removal, finding higher bone density in mice without it.

Preprint: mouse studyBones and joints

Paper

Scientific ReportsApr 1

Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model

Experiments in miceMechanisms