BiomarkersHumans2,630 participants10 yearsCohort study

Accelerated Phenotypical Aging in Midlife is Associated With Long-Term Cognitive Decline

GSA 2025 Abstract

Abstract

PhenoAge, a multi-system biomarker uses easily-obtained common clinical blood tests and determines whether a person is younger or older on a biological and physiological level than expected by chronological age. Higher PhenoAge is associated with increased risk of disability, age-related morbidities and all-cause mortality.

The paper

Merten N, Baumann MR, Chappell R et al.

GSA 2025 Abstract · 31 Dec 2025 · CC BY

Presented at GSA 2025

doi.org/10.1093/geroni/igaf122.212