Abeta 1-42

1. Down syndrome increases Abeta 1-42 in humans.

   “DS individuals had consistently higher levels of Aß1‐37, 1‐38, 1‐40, and 1‐42 compared to CS general population adults, sporadic pAD/AD, and those with PS1 mutations.”

   HumansDown syndromeplasma

   Amyloid‐beta subspecies in individuals with Down Syndrome, sporadic Alzheimer's disease (sAD) and PS1 mutations ‐ comparison using IP‐Mass Spectrometry of plasma

   AAIC 2025 abstract·8 Jan 2026

More on Down syndrome