Abeta 1-40/1-37 ratio

1. Down syndrome increases Abeta 1-40/1-37 ratio in humans.

   “DS pAD/ AD had increased Aß ratios for 1‐ 40/1‐37 and 1‐37/ 1‐38 compared to sporadic pAD/AD”

   HumansDown syndrome prodromal or with ADplasma

   Amyloid‐beta subspecies in individuals with Down Syndrome, sporadic Alzheimer's disease (sAD) and PS1 mutations ‐ comparison using IP‐Mass Spectrometry of plasma

   AAIC 2025 abstract·8 Jan 2026

More on Down syndrome