3-methylhistidine

1. Urolithin A has no effect on 3-methylhistidine in humans (Δ = -3.20 ± 0.31 μmol/L, p = 0.36).

   “When compared to the placebo group, there was no significant difference observed in 3-MH in the UA group (Δ=-3.20 ± 0.31 μmol/L, p = 0.36).”

   Human trial1 g daily8 weeksmales

   Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study

   Journal of the International Society of Sports Nutrition·Nov 2, 2024

More on Urolithin A

1. Exercise increases 3-methylhistidine in humans.

   “The urinary excretion levels of creatinine, 3-methylhistidine (3-MH), aldosterone, and catecholamines, and the 3-MH/creatinine ratio were significantly increased only during the exercise regimen.”

   Human trial5 daysmalesn = 6

   Body weight reduction by exercise increases the urinary 3-methylhistidine excretion level with relatively positive nitrogen, sodium, and potassium balances when compared to dietary restriction

   Heliyon·Sep 1, 2023

More on Exercise

1. Creatine decreases 3-methylhistidine in humans (-40% vs +29% PLA, P < 0.05).

   “Subjects receiving creatine (C and CP) experienced a decrease in 3-MH by 40% compared with an increase of 29% for PLA (P < 0.05)”

   Human trialduring resistance training10 wkmales

   Low-dose creatine combined with protein during resistance training in older men

   Medicine and science in sports and exercise·Sep 1, 2008

More on Creatine

1. Type 2 diabetes is associated with 3-methylhistidine in humans.

   “Older adults with F-T2DM showed an amino acid profile characterized by higher levels of 3-methylhistidine, alanine, arginine, ethanolamine, and glutamic acid.”

   Humansfrail/pre-frail with type 2 diabetes mellitusn = 66

   Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies

   Metabolites·Apr 10, 2023

More on Type 2 diabetes