196 results
Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.
In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.
In aged mice, lacking Sestrin1 worsened liver cell senescence and fat buildup, and the protein proved indispensable for the liver benefits of exercise.In aged mice, lacking Sestrin1 worsened liver cell senescence and fat buildup, and the protein proved indispensable for the liver benefits of exercise.
The algorithm’s accuracy measures exceeded 84.8% against a reference device in a randomised trial of 406 postmenopausal women who were overweight.The algorithm’s accuracy measures exceeded 84.8% against a reference device in a randomised trial of 406 postmenopausal women who were overweight.
At six months, the model’s ability to distinguish cancer cases from non-cases scored 0.88 in development, 0.89 in internal validation and 0.86 in external validation.At six months, the model’s ability to distinguish cancer cases from non-cases scored 0.88 in development, 0.89 in internal validation and 0.86 in external validation.
Metformin users had lower blood clot risk than non-users, with a hazard ratio of 0.78, a measure comparing risk over time.Metformin users had lower blood clot risk than non-users, with a hazard ratio of 0.78, a measure comparing risk over time.
A randomised, double-blind trial also found changes in gut bacteria, including suppression of bacteria that produce an enzyme involved in processing bile acids.A randomised, double-blind trial also found changes in gut bacteria, including suppression of bacteria that produce an enzyme involved in processing bile acids.
In data from 720,000 people, the self-evolving system evaluated 2,031 causal questions and identified blood pressure as a convergence node for vascular outcomes.In data from 720,000 people, the self-evolving system evaluated 2,031 causal questions and identified blood pressure as a convergence node for vascular outcomes.
Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects.Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects.