Review26 Sep 2026

Active Human Transposable Elements: Long-Read Sequencing Technologies, Computational Analysis, and Implications for Human Disease

Biomolecules

Abstract · CC BY

Transposable elements (TEs) account for nearly half of the human genome and shape chromatin organization, gene regulation, and genome evolution. However, their contributions to human physiology and disease remain incompletely understood.

The paper

Vörösvácki D, Szakállas N, Kalmár A et al.

Biomolecules · 27 Aug 2026

doi.org/10.3390/biom16091247 PubMed

AnimalsmTOR & rapamycin1 h

Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice

The mTOR inhibitor restored macrophage efferocytosis and mitochondrial function while lowering aortic lipid burden in high-fat-fed ApoE-deficient mice.

International Immunopharmacology · Wang Y et al.

AnimalsCellular senescence1 h

Jianwei Shoutai Pills reduce uterine aging and pregnancy loss in aged mice

The herbal formula delayed thymic involution, restored regulatory T cell function, and improved maternal-fetal immune tolerance by altering metabolic signaling in aging female mice.

Phytomedicine · Guan F et al.

Cells1 h

Loss of lncRNA H19 suppresses osteoblast differentiation under oxidative stress

Overexpressing the noncoding RNA restored bone healing in mice, separating impaired osteogenesis from the onset of cellular senescence.

Bone · Shin HR et al.

CellsPreprint3 h

Aged human muscle secretes an enzyme that impairs stem cell maintenance

Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.

bioRxiv · Crisol B et al.

Active Human Transposable Elements: Long-Read Sequencing Technologies, Computational Analysis, and Implications for Human Disease

The paper

Latest stories

Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice

Jianwei Shoutai Pills reduce uterine aging and pregnancy loss in aged mice

Loss of lncRNA H19 suppresses osteoblast differentiation under oxidative stress

Aged human muscle secretes an enzyme that impairs stem cell maintenance