NPJ Digital Medicine

Sleep patterns in dementia differed from typical aging

After risk scores were grouped, the model identified 75.7% of dementia cases and correctly classified 74.7% of controls using data not used for training.

Paper by Nan Fletcher-Lloyd, Nathalia Céspedes, Alexander Capstick, +9 more authorsPayam Mamaani Barnaghi · UK Dementia Research Institute · Great Ormond Street Hospital

Our read

Biomarkers
Studied:
Cohort study of 1,672 people from the general population and a dementia cohort, against controls
What changed:
The model identified 75.7% of dementia cases and correctly classified 74.7% of controls using unseen data
The catch:
The comparison with clinical judgment was a pilot in only 50 high-risk people

Editor of record: Boris Djordjevic · AgingResearch.News

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People from the general population and a dementia cohort, totaling 1,672 participants, contributed under-the-mattress sleep sensor data to an observational study. Researchers developed a computer model to estimate age from repeated sleep measurements, then used deviations from typical age-related patterns to assess dementia risk. They grouped risk scores into high, medium and low categories.

Sleep patterns in people with dementia departed from typical aging patterns. These deviations were associated with irregular times for going to bed and getting up, and with less night-to-night variation in deep sleep. On data held back from training, the model’s age estimates were off by an average of 5.52 years.

Why it matters

For dementia risk screening, the authors suggest that remote sleep monitoring may help identify people who could benefit from further clinical evaluation.

Caveats

Separating dementia cases from controls is not the same as predicting who will develop dementia. The comparison with clinical judgment was a pilot involving 50 high-risk people.

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