Microglial Senescence in Neurodegenerative Diseases: Mechanisms and Therapeutic Perspectives

The global aging population has led to a rising incidence of neurodegenerative diseases, casting a significant shadow on global health due to their complex and multifactorial nature. In addition to genetic predispositions, cellular senescence, particularly in microglia, the innate immune cells of the central nervous system, has become a significant contributor to neurodegeneration. In this review, we examine the mechanism of microglial senescence in neurodegenerative disease. We emphasize the need for continuous exploration of microglial senescence mechanisms and provide a future perspective for developing preventive drugs, encouraging researchers to develop new therapies for patients with neurodegenerative diseases.