Biological significance of the NF-κb mechanism in aging

Cellular aging is one of the fundamental biological processes, which consists of irreversible blocking of cell division under the influence of external or internal factors. The article presents data showing that NF-κB is important in the aging process. Its various functions are associated with the main features of this process, such as changes in intercellular communication, DNA damage, oxidative stress, inflammation, and mitochondrial dysfunction. A stimulating agent activates the NF-κB signaling pathway, and IκB is phosphorylated by IKK kinase (IκB kinase), which leads to IκB degradation. In this case, NF-κB is released from the inhibitory complex, translocates to the nucleus, and activates transcription of controlled genes. Thus, there is evidence of the participation of NF-κB in the processes of aging, carcinogenesis, regulation of proliferation, and apoptosis. However, the role of NF-κB in age-related changes in organs has not been sufficiently studied, and therefore additional research is required.