Association of age-related viability with systemic inflammation in low-energy fractures

The study of biomarkers of age-related viability (resilience) in gerontology and geriatrics is actively continuing, but it has practically not been considered in patients with low-energy fractures. The aim of the study was to analyze the association of age-related viability with systemic inflammation in low-energy fractures. Among 102 patients after 2,5-3 months of low-energy fractures, stability in the motor and cognitive domains of walking speed, the 6-minute walking test and MMSE, respectively, were studied. A decrease in the motor domain was found in 78,43±3,61% of cases and the cognitive domain in 67,65±3,12% of cases (p<0,01). In patients with a decrease in the motor domain, the content of all pro-inflammatory cytokines is significantly higher compared to representatives with a decrease in the cognitive domain. This is especially true for the level of IL-6, which in patients with decreased motor domain was 30,4±1,5 pg/ml versus 12,1±0,8 pg/ml, TNF-α was 41,2±2,3 and 17,6±0,9 pg/ml, and IL-1b was 24,8±1,6 and 10,6±0,7 pg/ml, respectively. Multiple beta regression coefficients show a negative association with pro-inflammatory cytokines among both patients with low-energy fractures with a decrease in the motor domain and a decrease in the cognitive domain. However, the association with IL-10 is positive and the β coefficient was +1,95 for a decrease in the motor domain and +1,32 for a decrease in the cognitive domain.