Mitochondria-associated membranes (MAMs) in age-related heart diseases, role of endoplasmic reticulum stress

The study of interoganellar contactology represents a substantial advance in conceiving cells and their organelles. This presents a great challenge in terms of understanding their function and response to aging and in the development of different pathologies. This chapter will address changes in mitochondria-associated membranes (MAMs) in aging-related heart diseases, such as acute myocardial infarction and heart failure, emphasizing the role of endoplasmic reticulum stress (ERS). We also discuss the role of MAMs as possible markers of cardiovascular disease progression in geriatrician clinics, with a view to personalized therapy. Finally, we will contemplate the use of naturally occurring drugs that have been used in the experimental setting for the regulation of mitochondrial-ER communication. (119 words).