Host-microbe interactions in NAD⁺ metabolism

Nicotinamide adenine dinucleotide (NAD⁺) is an essential cofactor for hundreds of biochemical reactions. Targeting NAD⁺ metabolism has been investigated as a therapeutic strategy for various metabolic, neurogenerative, and inflammatory conditions, including aging and cancer. Here we highlight recent advances in host-microbiome interactions regulating NAD⁺ metabolism and discuss their therapeutic potential.