Evaluating Fiber Orientation Dispersion Measures Computed From Single-Shell Diffusion MRI

Fiber orientation dispersion is one of the fundamental features that can be estimated from diffusion magnetic resonance imaging (dMRI) of the brain. Several approaches have been proposed to estimate dispersion from single- and multi-shell dMRI acquisitions. Here, we derive solutions to bring these proposed methods to a standard orientation dispersion index (ODI) with the goal of making them comparable across different dMRI acquisitions. To illustrate the utility of the measures in studying brain aging, we further examined the age-dependent trajectory of the different single- and multi-shell ODI estimates in the white matter across the lifespan.Clinical Relevance- This work computes metrics of brain microstructure that can be adapted for large neuroimaging initiatives that aim to study the brain's development and aging, and to identify deviations that may serve as biomarkers of brain disease.