Metabolic biomarkers and their association with impaired glomerular filtration in older adults

The burden of renal complications is increasing due to the high prevalence of noncommunicable diseases in the global population and the lack of accurate diagnostic tools to assess glomerular filtration status. In response to this situation, this study aimed to analyze metabolic biomarkers and their association with impaired glomerular filtration in older adults. This was a descriptive systematic review that used the PRISMA 2020 guideline as the protocol for its preparation. Articles published between 2021 and 2026 and included based on eligibility criteria were accessed through sources of high scientific relevance such as PubMed, Embase and Scopus, supported by a combined search strategy (AND and OR). The results demonstrated that interleukin-10, kidney injury molecule-1, beta microglobulin and cystatin C are associated with renal function. In addition, the calculation of CKD-EPI together with other biochemical indicators allows glomerular filtration status to be revealed. Finally, tumor necrosis factor alpha, cystatin C, serum creatinine, beta-microglobulin, apolipoprotein M, 3-methylglutarylcarnitine and the atherogenic index of plasma show a significant association with this complication. It is concluded that impaired glomerular filtration can become a controllable problem in the aging population if an optimal lifestyle is adopted alongside constant monitoring of renal function.