Research Synthesis: Nad Effects — full paper

Researka accepted publication: ca403171-b282-4695-8058-9dd6bfe3754b Source submission: 851f4e54-fdaa-48f2-a082-cadc97609cd5 Evidence-honesty note: 15/29 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that the source texts contain no directional findings; source-level positive, negative, or unclear findings should be interpreted through the coded outcome class, directness, and claim-count fields. 27/29 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims. This paper synthesizes nad effects as an aging-related intervention across 29 included source papers and 1640 high-confidence extracted claims. The evidence profile contains 2 direct clinical sources, 20 adjacent clinical sources, and 2 mechanistic or model-system sources, with 98 cross-study disagreements across the evidence base. Positive study-level signals are summarized in the contextual adjacent evidence, immune and inflammation outcome classes, null signals in the contextual adjacent evidence, cardiometabolic, dosing and pharmacokinetics outcome classes, and negative signals in the longevity and contextual adjacent evidence outcome classes.