Positive ageing profiles: confirmation and extension in the Health and Retirement Study and the English Longitudinal Study of Ageing

A prior, exploratory analysis of the NHANES 1999–2002 DNA-methylation subsample [will insert discovery paper / preprint url here] found that cumulative social adversity was associated with a faster pace of epigenetic ageing; that a "resilient residual" (ageing more slowly than adversity predicts) predicted lower all-cause mortality; and that physical activity was protective while current smoking and heavy alcohol were risks (moderate alcohol was equivalent to none). This study tests whether those findings replicate in two independent, harmonised ageing cohorts and extends the resilience model to a pre-specified psychosocial protective factor, social support.