Research Synthesis: Chronic low-grade inflammation

Researka accepted publication: 073c460c-0262-46c7-88e4-bc96b9c25668 Source submission: 1017658b-fd94-47c3-8318-8b274e570656 This paper synthesizes evidence on Chronic low-grade inflammation across 60 accepted source papers and 1409 high-confidence extracted claims. The evidence profile contains 2 direct clinical sources, 54 adjacent clinical sources, and 4 mechanistic or model-system sources, with 163 cross-study disagreements across the evidence base. Positive study-level signals are summarized in the immune and inflammation, contextual adjacent evidence outcome classes, null signals in the contextual adjacent evidence, immune and inflammation, longevity outcome classes, and negative signals in the immune and inflammation, longevity outcome classes. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect. The conclusion is that Chronic low-grade inflammation remains a bounded geroscience case: the retained clinical and mechanistic evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim. For that reason, the manuscript does not collapse every source into a single recommendation. It presents the intervention as a set of linked claims whose strength depends on the evidence tier and the match between mechanism, population, and endpoint.