Hypothesis-Generating Brief: Omega 3 longevity — full paper

Researka accepted publication: 76c1eee1-5a49-4262-ad24-e968d6c1e96c Source submission: ed8b9edb-8d5d-44ad-8452-99fdcd51f340 Evidence-honesty note: 24/48 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that the source texts contain no directional findings; source-level positive, negative, or unclear findings should be interpreted through the coded outcome class, directness, and claim-count fields. 39/48 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims. This paper synthesizes evidence on Omega 3 longevity across 48 accepted source papers and 2985 high-confidence extracted claims. The evidence profile contains 9 direct clinical sources, 38 adjacent clinical sources, and 1 mechanistic or model-system source, with 389 cross-study disagreements across the evidence base. Positive study-level signals are summarized in the contextual adjacent evidence, longevity, safety and comorbidity outcome classes, null signals in the contextual adjacent evidence, muscle function and cardiometabolic outcome classes, and negative signals in the immune and inflammation outcome class.