Lateral ventricle size
Biomarker1 paper2 findings
- Animals1
Interventions
2Fisetin
downin mice1Very low certainty
1 study
Fisetin
downin mice1Very low certainty
Fisetin decreases lateral ventricle size in mice.
“Both senolytic treatments were equally protective against neurodegeneration as evidenced by smaller lateral ventricle size in senolytic treated rTg4510s compared to those vehicle treated.”
Animalsin rTg4510 micebrain12 weeks
HIGH RESOLUTION SPATIAL PROTEOGENOMICS TO ASSESS TARGET ENGAGEMENT AND COMPARE SENOLYTIC EFFICACY IN THE BRAIN OF TAU TRANSGENIC MICE · GSA 2024 abstract · 31 Dec 2024
Dasatinib + quercetin
downin mice1Very low certainty
1 study
Dasatinib + quercetin
downin mice1Very low certainty
Dasatinib + quercetin decreases lateral ventricle size in mice.
“Both senolytic treatments were equally protective against neurodegeneration as evidenced by smaller lateral ventricle size in senolytic treated rTg4510s compared to those vehicle treated.”
Animalsin rTg4510 micebrain12 weeks
HIGH RESOLUTION SPATIAL PROTEOGENOMICS TO ASSESS TARGET ENGAGEMENT AND COMPARE SENOLYTIC EFFICACY IN THE BRAIN OF TAU TRANSGENIC MICE · GSA 2024 abstract · 31 Dec 2024