Bombyx mori

1. Dopamine shortens lifespan in B. mori.

   “Reducing dopamine levels shortened lifespan”

   Model organismsreducing dopamine levels

   Dopamine Enhances Healthspan and Locomotor Performance via Antioxidant Defense in Silkworms, Bombyx mori

   Insects·14 Feb 2026

2. Dopamine protects against oxidative stress and ROS signalling in B. mori.

   “lifespan-extending effect of dopamine was closely correlated with enhanced total antioxidant capacity”

   Model organismsmoderate peripheral administration or elevated endogenous levels

   Dopamine Enhances Healthspan and Locomotor Performance via Antioxidant Defense in Silkworms, Bombyx mori

   Insects·14 Feb 2026

3. Dopamine improves locomotor activity in B. mori.

   “improved locomotor activity, and restored motor vigor in aged moths”

   Model organismsmoderate peripheral administration

   Dopamine Enhances Healthspan and Locomotor Performance via Antioxidant Defense in Silkworms, Bombyx mori

   Insects·14 Feb 2026

4. Dopamine improves healthspan in B. mori.

   “moderate peripheral administration significantly extended healthspan, improved locomotor activity, and restored motor vigor in aged moths”

   Model organismsmoderate peripheral administration

   Dopamine Enhances Healthspan and Locomotor Performance via Antioxidant Defense in Silkworms, Bombyx mori

   Insects·14 Feb 2026

More on Dopamine

1. Nicotinic acid extends adult lifespan in B. mori.

   “Supplementation with nicotinic acid (NA) significantly reversed these aging-associated changes both in vitro and in vivo, including improved redox balance, reduced oxidative stress markers, and prolonged adult lifespan.”

   Model organisms

   Silkworm as a model for NAD⁺-dependent lifespan regulation: Functional insights into BmNmnat1 and nicotinic acid

   Insect science·30 Jan 2026

More on Nicotinic acid