Zinc and metformin co-functionalized polyetheretherketone

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Natural Science Foundation of Shenzhen City and 4 more

Animals1

Outcomes

Osseointegration

upin rats1

1 study

Zinc and metformin co-functionalized polyetheretherketone improves osseointegration in rats.
“ultimately resulting in enhanced osseointegration in aged rats.”
Animalszinc- and metformin-functionalized polyetheretherketone
Zinc and metformin co-functionalized polyetheretherketone: A novel dental implant material tailored for the elderly
Journal of advanced research27 Aug 2025

Cellular senescence

downin rats1

1 study

Zinc and metformin co-functionalized polyetheretherketone inhibits cellular senescence in rats.
“ZnMet@PEEK exhibited excellent biocompatibility, significantly inhibited inflammation, promoted bone formation, and inhibited cellular senescence, ultimately resulting in enhanced osseointegration in aged rats.”
Animalszinc- and metformin-functionalized polyetheretherketone
Zinc and metformin co-functionalized polyetheretherketone: A novel dental implant material tailored for the elderly
Journal of advanced research27 Aug 2025

Latest

Journal of Advanced Research30 Aug