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Young extracellular vesicles

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Institute of General Medical Sciences and 1 more
  • Animals1

Outcomes

3

Oxidative phosphorylation

upin mice1

1 study

  1. Young extracellular vesicles improve oxidative phosphorylation in mice.

    “EV therapy reestablishes immuno-metabolic function, mitochondrial bioenergetics, immune cell infiltration and adipose tissue function.”

    Animalsin older mice after burn injuryadipose tissue

    Young extracellular vesicles restore burn-induced adipose tissue immunometabolic and mitochondrial function in older mice

    Scientific reports9 Oct 2025

More on Oxidative phosphorylation

Lipid and ceramide metabolism

downin mice1

1 study

  1. Young extracellular vesicles decrease lipid and ceramide metabolism in mice.

    “We further demonstrated that EVs mitigate lipolysis”

    Animalsin older mice after burn injury

    Young extracellular vesicles restore burn-induced adipose tissue immunometabolic and mitochondrial function in older mice

    Scientific reports9 Oct 2025

More on Lipid and ceramide metabolism

Cellular senescence

downin mice1

1 study

  1. Young extracellular vesicles decrease cellular senescence in mice.

    “EVs from young mouse serum samples significantly reduced burn-induced senescence in aged adipose tissue.”

    Animalsafter burn injuryadipose tissue

    Young extracellular vesicles restore burn-induced adipose tissue immunometabolic and mitochondrial function in older mice

    Scientific reports9 Oct 2025

More on Cellular senescence

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