Young bone marrow mesenchymal stem cell extracellular vesicles
2 papers study it3 findings
Across all fields, 2 papers: none in people yet, 2 in animals
- 2 independent labs in 2 countries
- Funders: National Health and Medical Research Council and others
- Animals2
Outcomes
3Stem cell differentiation
upin rat cells1
1 study
Stem cell differentiation
upin rat cells1
Young bone marrow mesenchymal stem cell extracellular vesicles increase stem cell differentiation in rat cells.
“In vitro, Y-EVs promoted osteogenic differentiation”
Cellsin aged bone marrow mesenchymal stem cells
Biomaterials
Cellular senescence
downin mouse cells1
1 study
Cellular senescence
downin mouse cells1
Young bone marrow mesenchymal stem cell extracellular vesicles decrease cellular senescence in mouse cells.
“EVs from young BMSCs markedly decreased senescence and improved chondroprotection by activating the PTEN pathway while simultaneously suppressing the upregulation of the PI3K/AKT pathways”
Cellsin chondrocytes under inflammatory responses in vitro
Cell proliferation
Osteoarthritis
downin mice1
1 study
Osteoarthritis
downin mice1
Young bone marrow mesenchymal stem cell extracellular vesicles protect against osteoarthritis in mice.
“intraperitoneal injections of EVs from young donors significantly mitigated OA progression by preserving cartilage and reducing synovitis in a surgical OA model using DMM in mice.”
Animalsin mouse model of DMM-induced OA
Cell proliferation