X-ray radiation
5 papers10 findings
- 4 independent labs in 5 countries
- 1 finding against
- Funders: Basic and Applied Basic Research Foundation of Guangdong Province and 2 more
- Animals4
- Cells1
Outcomes
8Cellular senescence
upin human cells1upin mice1
2 studies
Cellular senescence
upin human cells1upin mice1
X-ray radiation induces cellular senescence in mice.
“Low dose fractionated X-ray therapy induces cellular senescence in mouse liver tissues”
Animalsfractionated X-ray exposure (0.1, 0.2, or 0.5 Gy every 48 h, 16 times)liver
Radiation oncology (London, England)11 Apr 2026
X-ray radiation increases cellular senescence in human cells.
“decreased proliferation, increased senescence, and significant changes in hundreds of genes even after several cell generations.”
Cellsadipose tissue2 Gy
Molecular and Cellular Effects of CT Scans in Human Adipose Mesenchymal Stem Cells
International journal of molecular sciences3 Sep 2025
Lifespan
downin mice1no changein mice1
2 studies
Lifespan
downin mice1no changein mice1
X-ray radiation shortens lifespan in mice.
“The life span shortening by X-rays was proportional to dose, while carbon ions produced a convex upward relationship.”
Animalswhole-body X-ray-irradiation4 consecutive weeks
Effect of carbon ions on life span shortening and tumorigenesis in mice
Uchu Seibutsu Kagaku1 Nov 2004
X-ray radiation has no effect on lifespan in mice.
“The results showed no significant differences in lifespan between experimentals and controls.”
Animalsin first-generation offspring conceived >7 weeks post-irradiation
Lifespan and autopsy findings in the first-generation offspring of X-irradiated male mice
Mutation research1 Sep 1993
Liver edema
upin mice1
1 study
Liver edema
upin mice1
X-ray radiation induces liver edema in mice.
“Compared with the control group, hepatocytes in the 0.1 Gy × 16 group showed mild edema; hepatocytes in the 0.2 Gy × 16, and 0.5 Gy × 16 groups all showed mild to moderate edema”
Animalsfractionated X-ray exposure (0.1–0.5 Gy × 16)liver
Radiation oncology (London, England)11 Apr 2026
Oxidative stress and ROS signalling
upin mice1
1 study
Oxidative stress and ROS signalling
upin mice1
X-ray radiation increases oxidative stress and ROS signalling in mice.
“the levels of MDA, SOD and GSH in the liver and the levels of 8-OHdG in both serum and liver of mice increased with increasing radiation dose.”
Animalsfractionated X-ray exposure (16 times)liver
Radiation oncology (London, England)11 Apr 2026
CDKN2A
upin mice1
1 study
CDKN2A
upin mice1
X-ray radiation increases CDKN2A in mice.
“Compared with the control group, p53, p21, p16 mRNA and protein levels were significantly higher in the 0.2 Gy × 16 and 0.5 Gy × 16 groups (p < 0.05)”
Animals0.2 Gy and 0.5 Gy fractionated radiation (16 times)liver
Radiation oncology (London, England)11 Apr 2026
Senescence-associated beta-galactosidase
upin mice1
1 study
Senescence-associated beta-galactosidase
upin mice1
X-ray radiation increases senescence-associated beta-galactosidase in mice.
“The degree of SA-β-Gal staining of liver was increased in all dose groups compared to the control group.”
Animalsfractionated X-ray exposure (0.1, 0.2, or 0.5 Gy every 48 h, 16 times)liver
Radiation oncology (London, England)11 Apr 2026
Proliferation
downin human cells1
1 study
Proliferation
downin human cells1
X-ray radiation decreases proliferation in human cells.
“A high dose of 2 Gy X-ray exposure caused sustained DNA damage, decreased proliferation, increased senescence”
Cellsadipose tissue2 Gy
Molecular and Cellular Effects of CT Scans in Human Adipose Mesenchymal Stem Cells
International journal of molecular sciences3 Sep 2025
Neoplasm
no changein mice1
1 study
Neoplasm
no changein mice1
X-ray radiation has no effect on neoplasm in mice.
“Likewise, there were no significant differences between experimentals and controls in the frequency, severity, or age distribution of neoplasms and other diseases.”
Animalsin first-generation offspring conceived >7 weeks post-irradiation
Lifespan and autopsy findings in the first-generation offspring of X-irradiated male mice
Mutation research1 Sep 1993