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Within-ejaculate sperm selection

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 2 countries
  • Funders: Biotechnology and Biological Sciences Research Council and 1 more
  • Humans1

Outcomes

1

Molecular signatures of age-related disease

downin human cells1

1 study

  1. Within-ejaculate sperm selection decreases molecular signatures of age-related disease in human cells.

    “we find that this selection is biased against molecular signatures of age-related disease.”

    Cellshealthy donorsspermmales

    Within-ejaculate sperm selection in humans acts against molecular signatures of age-related disease

    bioRxiv (Cold Spring Harbor Laboratory)Oct 9, 2024Preprint

More on Molecular signatures of age-related disease

Associations

1

Senescence-associated genes involved in genome maintenance and oxidative stress response

upin human cells1

1 study

  1. Within-ejaculate sperm selection is associated with senescence-associated genes involved in genome maintenance and oxidative stress response in human cells.

    “genes diverging under sperm longevity-based selection are enriched for senescence-associated genes involved in genome maintenance and oxidative stress response.”

    Cellsgenes diverging under selection in healthy donorslongevity-based selectionspermmales

    Within-ejaculate sperm selection in humans acts against molecular signatures of age-related disease

    bioRxiv (Cold Spring Harbor Laboratory)Oct 9, 2024Preprint

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