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WIP1 inhibitor

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Agence Nationale de la Recherche and 6 more
  • Animals1

Outcomes

3

Inflammation

no changein mice1

1 study

  1. WIP1 inhibitor has no effect on inflammation in mice.

    “selective inhibition of WIP1 does not promote kidney fibrosis or inflammation.”

    Animalsin experimental collapsing glomerulopathy

    Targeting WIP1 phosphatase promotes partial remission in experimental collapsing glomerulopathy

    Kidney internationalFeb 27, 2024

More on Inflammation

Kidney disease severity

downin mice1

1 study

  1. WIP1 inhibitor decreases kidney disease severity in mice.

    “and ameliorated kidney histopathologic features.”

    Animalsin i-TERTci and Tg26 mice

    Targeting WIP1 phosphatase promotes partial remission in experimental collapsing glomerulopathy

    Kidney internationalFeb 27, 2024

Proteinuria

downin mice1

1 study

  1. WIP1 inhibitor decreases proteinuria in mice.

    “Pharmacologic inhibition of WIP1 enzymatic activity in either the telomerase mice with CG or in the Tg26 mice promoted partial remission of proteinuria”

    Animalsin i-TERTci and Tg26 mice

    Targeting WIP1 phosphatase promotes partial remission in experimental collapsing glomerulopathy

    Kidney internationalFeb 27, 2024

More on Proteinuria

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