Vsl#3

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funders: Chinese Academy of Medical Sciences and 1 more

Animals2

Outcomes

Inflammation

downin mice1

1 study

Vsl#3 decreases inflammation in mice.
“The probiotic VSL#3 ameliorated gut dysbiosis, alleviated POCD, and reduced neuroinflammation.”
Animalspostoperative cognitive dysfunctionhippocampusmales
Mechanism of the AMPK/SIRT1 pathway in gut dysbiosis-mediated postoperative cognitive dysfunction in aged mice
The international journal of neuropsychopharmacology1 Oct 2025

Associations

Colitis

downin mice1

1 study

Vsl#3 lowers the risk of colitis in mice.
“CB and VSL#3 alleviated colitis, evidenced by significantly lower DAI and histopathologic scores and increased colon lengths.”
AnimalsDSS-induced acute colitisgavagecolonmales
Probiotics reduce the severity of DSS-induced colitis in aged mice by enhancing intestinal barrier function and modulating gut microbiota
GeroScience13 Oct 2025