Vertical sleeve gastrectomy

1. Vertical sleeve gastrectomy improves immune response in mice.

   “VSG and CR regimens exerted both similar and unique effects, as assessed using multiomics approaches, in reversing obesity-associated transcript, epigenetics, secretome, and microbiota changes and restoring antitumor immunity.”

   Animalsin a murine model of obesity-driven TNBC

   Calorie restriction outperforms bariatric surgery in a murine model of obesity and triple-negative breast cancer

   JCI insight·Sep 12, 2023

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1. Vertical sleeve gastrectomy decreases tumor growth in mice.

   “Each intervention generated weight and fat loss and suppressed tumor growth relative to obese mice (greatest suppression with CR).”

   Animalsrelative to obese mice

   Calorie restriction outperforms bariatric surgery in a murine model of obesity and triple-negative breast cancer

   JCI insight·Sep 12, 2023

1. Vertical sleeve gastrectomy decreases glucose excursions in mice (lowered by ∼30% in wild-type mice but by ∼20% in SGLT2-null animals).

   “with glucose excursions following intraperitoneal injection lowered by ∼30% in wild-type mice but by ∼20% in SGLT2-null animals.”

   Animalsfollowing intraperitoneal injection in wild-type mice

   Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney

   Diabetes·May 20, 2022

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1. Vertical sleeve gastrectomy decreases SLC5A2 in mice.

   “the expression of sodium-glucose cotransporter 2 (SGLT2/Slc5a2) is reduced in the kidney of lean and obese mice following vertical sleeve gastrectomy (VSG).”

   Animalsin lean and obese micekidney

   Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney

   Diabetes·May 20, 2022

More on SLC5A2