Proneurotensin

1. Glucagon-like PEPTIDE-1 has no effect on proneurotensin in humans.

   “GIP or GLP-1 infusion had no effect on pNT levels.”

   Human trialinfusion

   The Effects of Calorie Restriction and Bariatric Surgery on Circulating Proneurotensin Levels

   The Journal of clinical endocrinology and metabolism·Mar 13, 2024

More on Glucagon-like PEPTIDE-1

1. Bariatric surgery increases proneurotensin in humans.

   “Prior to RYGB, all patients lacked a meal response in pNT, but this was evident post RYGB/VSG.”

   Human trialpost RYGB/VSG

   The Effects of Calorie Restriction and Bariatric Surgery on Circulating Proneurotensin Levels

   The Journal of clinical endocrinology and metabolism·Mar 13, 2024

More on Bariatric surgery

1. Roux-en-y gastric bypass decreases proneurotensin in humans.

   “Reduced fasting and postprandial pNT were evident after VLED and immediately following RYGB.”

   Human trialimmediately following RYGB

   The Effects of Calorie Restriction and Bariatric Surgery on Circulating Proneurotensin Levels

   The Journal of clinical endocrinology and metabolism·Mar 13, 2024

More on Roux-en-y gastric bypass

1. Caloric restriction decreases proneurotensin in humans.

   “Reduced fasting and postprandial pNT were evident after VLED”

   Human trialafter very low-energy diet

   The Effects of Calorie Restriction and Bariatric Surgery on Circulating Proneurotensin Levels

   The Journal of clinical endocrinology and metabolism·Mar 13, 2024

More on Caloric restriction