Tyrphostin ag 490
- 3 independent labs in 2 countries
- Funders: National Natural Science Foundation of China and 4 more
- 1 of 6 findings with company ties
- Humans1
- Animals2
Outcomes
5Cellular senescence
downin human cells1downin mice1
2 studies
Cellular senescence
downin human cells1downin mice1
Tyrphostin ag 490 decreases cellular senescence in human cells.
“elevated senescence-associated secretory phenotype (SASP) and senescence in UC-MSCs and could be reversed by a specific JAK inhibitor AG490.”
Cellsin liver fibrotic factor-treated UC-MSCs
Cell death discoveryJul 28, 2023
Tyrphostin ag 490 decreases cellular senescence in mice.
“AG490 treatment reduced oxidative DNA damage and cellular senescence in the brains of mice following ischemic stroke”
Animalsischemic strokebrain
Experimental neurologyJul 5, 2023
Senescence-associated secretory phenotype (SASP)
downin humans1
1 study
Senescence-associated secretory phenotype (SASP)
downin humans1
Tyrphostin ag 490 decreases senescence-associated secretory phenotype (SASP) in humans.
“similarly to the senotherapeutic compound AG490”
Human trialex vivo tendon biopsiestendon
Bone & joint researchFeb 25, 2025
Inflammation
downin mice1
1 study
Inflammation
downin mice1
Tyrphostin ag 490 decreases inflammation in mice.
“reduced expression of pro-inflammatory cytokines, and decreased activation of pro-inflammatory microglia”
Animalsischemic strokebrain
Experimental neurologyJul 5, 2023
Brain infarct volume
downin mice1
1 study
Brain infarct volume
downin mice1
Tyrphostin ag 490 decreases brain infarct volume in mice.
“reduced brain infarct volume”
Animalsischemic strokebrain
Experimental neurologyJul 5, 2023
Neurobehavioral defects
upin mice1
1 study
Neurobehavioral defects
upin mice1
Tyrphostin ag 490 improves neurobehavioral defects in mice.
“alleviated neurobehavioral defects”
Animalsischemic strokebrain
Experimental neurologyJul 5, 2023