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Two-chemical combination

Intervention

1 paper studies it4 findings

Across all fields, 1 paper: none in people yet, 1 in animals

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Science Foundation and 3 more
  • 4 of 4 findings with company ties
  • Model organisms1

Outcomes

4

Healthspan

upin worms1

1 study

  1. Two-chemical combination improves healthspan in worms.

    “in vivo application of this two-chemical combination significantly extended C. elegans lifespan and healthspan.”

    Model organisms

    Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan

    EMBO molecular medicine

Lifespan

upin worms1

1 study

  1. Two-chemical combination extends lifespan in worms.

    “in vivo application of this two-chemical combination significantly extended C. elegans lifespan and healthspan.”

    Model organisms

    Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan

    EMBO molecular medicine

Oxidative stress and ROS signaling

downin human cells1

1 study

  1. Two-chemical combination decreases oxidative stress and ROS signaling in human cells.

    “we identified an optimized combination of two reprogramming molecules sufficient to induce the amelioration of additional aging phenotypes including cellular senescence and oxidative stress.”

    Cells

    Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan

    EMBO molecular medicine

More on Oxidative stress and ROS signaling

Cellular senescence

downin human cells1

1 study

  1. Two-chemical combination decreases cellular senescence in human cells.

    “we identified an optimized combination of two reprogramming molecules sufficient to induce the amelioration of additional aging phenotypes including cellular senescence and oxidative stress.”

    Cells

    Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan

    EMBO molecular medicine

More on Cellular senescence

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